Perineuronal nets stabilize the grid cell network
نویسندگان
چکیده
منابع مشابه
Perineuronal nets in neurodegeneration
At the end of the 19 th century, Camillo Golgi discovered that neurons were enwrapped by a net, but it was only recently that neuroscientists started to intensely investigate the role of this mysterious reticular structure. Today, perineuronal nets (PNNs) are known to be lattice-like extracellular matrix aggregates surrounding synapses at the soma, proximal axons and dendrites of several types ...
متن کاملDiverse functions of perineuronal nets.
Perineuronal nets represent well-organised components of the extracellular matrix, which are surrounding cell bodies, dendrites, and axon segments of a particular class of neurones as well as forming lattice-like structures. The role of perineuronal nets is not fully elucidated yet. Perineuronal nets may play a beneficial role by stabilizing the extracellular milieu assuring the characteristic ...
متن کاملSpatial patterns and cell surface clusters in perineuronal nets.
Perineuronal nets (PNN) ensheath GABAergic and glutamatergic synapses on neuronal cell surface in the central nervous system (CNS), have neuroprotective effect in animal models of Alzheimer disease and regulate synaptic plasticity during development and regeneration. Crucial insights were obtained recently concerning molecular composition and physiological importance of PNN but the microstructu...
متن کاملPerineuronal Nets and CNS Plasticity and Repair
1Department of Neuroscience, Neuroscience Institute of Turin (NIT), University of Turin, 10100 Turin, Italy 2Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (NICO), Regione Gonzole 10, Orbassano, 10043 Turin, Italy 3Netherlands Institute for Neuroscience (NIN), 1105 BA Amsterdam, Netherlands 4John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University o...
متن کاملAggrecan glycoforms contribute to the molecular heterogeneity of perineuronal nets.
The perineuronal net forms the extracellular matrix of many neurons in the CNS, surrounding neuron cell bodies and proximal dendrites in a mesh-like structure with open "holes" at the sites of synaptic contacts. The perineuronal net is first detected late in development, approximately coincident with the transformation of the CNS from an environment conducive to neuronal growth and motility to ...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2021
ISSN: 2041-1723
DOI: 10.1038/s41467-020-20241-w